| SJBALL006 |
D-G-R1 |
B |
4.8 |
na |
B-other |
MEF2D |
Second Primary Tumor |
CDKN2A del |
MEF2D-BCL9 fusion |
RB1 del |
N |
Second Primary Tumor |
N |
N |
na |
| SJBALL013
|
D-G-R1-R2 |
B |
4.3 |
2.1 |
nd |
nd |
Minor (D-R1), Major (R1-R2) |
CREBBP and ADD3 subclonal |
VPREB1, PAX5del, ETV6del |
EPOR (subclonal), CREBBP, RB1 and CDKN2A/B del |
Y, R=biphenotypic |
na |
N |
N |
na |
| SJBALL017
|
D-G-R1 |
B |
6.4 |
na |
Ph-like |
P2RY8-CRLF2 |
Minor |
JAK1, PAX5 |
PAX3, PTCH1, P2RY8-CRLF2 |
JAK1, KRAS (subclonal), PAX5del, CDKN2A/B del |
N |
na |
N |
N |
no |
| SJBALL021924
|
D-G-R1 |
B |
0.7 |
na |
Hyper |
nd |
Major |
None |
IKZF1del, PTCH1, ETV6, IKZF1 G183S, KRAS, CREBBP |
MLL2x2 sub, MLL3 sub |
N |
na |
N |
N |
na |
| SJBALL022426
|
D-G-R1 |
B |
2.7 |
na |
B-other |
iAMP21 |
Minor |
SETD2 |
Few, none recurrent |
PICALM, IKZF1, CDKN2A/B |
N |
Clonally related major clone |
N |
N |
no |
| SJBALL022427
|
D-G-R1 |
B |
2.8 |
na |
Ph-like |
nd |
Minor |
SOCS3 |
VPREB1, PAX5, ETV6, CDKN2A/B dels; FGFR1 and DDX6 muts |
ETV6del homo, EBF1 amp, PAX5-TP63 fusion |
N |
na |
N |
N |
na |
| SJBALL022428
|
D-G-R1 |
B |
0.3 |
na |
B-other |
nd |
Polyclonal |
TP53 sub becomes clonal; CCND3 |
TP53, B2M, DDX3X, BCL6, BTG1 (multiple), TCF3 (multiple) |
TP53 |
N |
na |
Y, Diagnosis |
N |
na |
| SJBALL022429
|
D-G-R1 |
B |
4.5 |
na |
DUX4 |
nd |
Minor |
None unique; TP53 sub becomes clonal |
VPREB1, IKZF1 dels; NRAS G13V, IGH-DUX4 fusion |
TBL1XR1 del |
N |
na |
N |
N |
no |
| SJBALL022430
|
D-G-R1 |
B |
7.2 |
na |
DUX4 |
nd |
Minor |
MLL2, FLT3 |
IKZF1, ARID2 dels, IGH-DUX4 fusion |
AKAP9; MLL2x2 sub |
N |
na |
N |
N |
no |
| SJBALL022431
|
D-G-R1 |
B |
3.7 |
na |
Ph-like |
P2RY8-CRLF2, iAMP21 |
Major |
FLT1 |
VPREB1, BTG1 dels; ATM, ABL1, ELF4, P2RY8-CRLF2 fusion |
NR3C1, CDKN2/B CNA; CHEK2, ROS1 |
N |
na |
N |
Y |
no |
| SJBALL022432
|
D-G-R1-R2 |
B |
2.9 |
6.8 |
Ph-like |
P2RY8-CRLF2 |
Minor (D-R2) |
None |
VPREB1, IKZF1, ETV6, CDKN2A/B CNA; CREBBP, P2RY8-CRLF2 fusion |
nd |
N |
na |
Y, Group 2 |
N |
na |
| SJBALL022477
|
D-G-R1 |
B |
3.3 |
na |
Hyper |
nd |
Minor |
None |
ARID5B del; PDGFRA |
CREBBP |
N |
na |
N |
N |
no |
| SJBALL022478
|
D-G-R1 |
B |
1.9 |
na |
MLL |
Ph-like |
Minor |
IL7R sub (lost); NRAS (rises) |
VPREB1, PAZ5, IKZF1, CDKN2A/B, KMT2A-TNS3;IKZF1-KMT2A;TNS3-IKZF1 fusions |
NRAS now clonal; DDX3X |
N |
na |
N |
N |
na |
| SJBALL022479
|
D-G-R1 |
B |
4.3 |
na |
Ph-like |
nd |
Minor |
LEF1 del, U2AF1 |
IKZF1, EBF1 dels; H3F3B mut; PAX5-JAK2 fusion |
SLX4IP, FHIT and ETV6 del; QKI and ADAR mut |
N |
na |
N |
N |
na |
| SJBALL022480
|
D-G-R1 |
B |
2.1 |
na |
Ph |
nd |
Polyclonal |
ERG sub, rises |
MLLT6 |
MED12, MECOM; MLLT10 and KDM6B (sub) |
N |
na |
N |
N |
no |
| SJBALL022481
|
D-G-R1 |
B |
3.2 |
na |
Hyper |
nd |
Minor |
CDKN2A/B, ADD3 del; PTPRT, CREBBP falls, CREBBP and MLH3 rise |
None clonal |
KRAS, ALK, SETD2, NCOR2, PBX1 |
N |
na |
N |
N |
na |
| SJBALL022482
|
D-G-R1-R2 |
B |
3.3 |
0.3 |
B-other |
TCF3-HLF |
Minor (D-R1), Minor (R1-R2) |
RB1, PAX5, BTG1 delns |
BRD4, TCF3-HLF fusion |
VPREB1, PAX5, APC2, RB1 CNAs; TBL1XR1, MEF2C, HLF muts sub, become clonal at R2;
DMD (lost) |
N |
Clonally related minor clone D->R1; Clonally related major clone R1 ->R2
|
N |
N |
na |
| SJBALL022483
|
D-G-R1-R2 |
B |
4.2 |
2.1 |
Hyper |
nd |
Polyclonal (D-R1), Polyclonal (R1-R2) |
FOXO1, RET sub, rise; NRAS, HOXA11, ROS1, ALK fall |
PAX5del, ARID5Bdel |
KRAS sub falls, CDKN2A/B 2copy del |
N |
na |
Y, Diagnosis |
N |
na |
| SJBALL022484
|
D-G-R1 |
B |
4.8 |
na |
Ph-like |
CRLF2 high |
Minor |
none recurrent |
SLX4IP, IKZF1 del |
IKZF1 del homo, RB1, NF1, CDKN2A/B del; NF1 homo |
N |
na |
N |
N |
no |
| SJBALL031
|
D-G-R1-S |
B |
7.9 |
1.1 |
nd |
nd |
Major (D-R1) |
FLT3 falls |
VPREB1, RN1, ETV6 dels; EZH2, CDKN2A, PTPN11 |
NF1, CDKN2A/B del; FANCC mut; TCF3-ZNF384 fusion |
Y, R= biphenotypic S=AML |
na |
N |
N |
S, not in study |
| SJBALL032
|
D-G-R1 |
B |
3.4 |
na |
Ph-like |
PAX5amp |
Major |
None recurrent (MAU2) |
PAX5amp, CDKN2A/Bdel, PAX5fs, BCL3, NRAS, MN1 |
RUNX1, MEF2C, BTLA del |
N |
na |
N |
N |
na |
| SJBALL036
|
D-G-R1 |
B |
4.0 |
na |
B-other |
ETV6-RUNX1-like |
Minor |
NF1, IKZF1 dels; TSC2, CREBBPx3 sub that rise; ETV6-EXTL1 fusion |
RAG1, PAX5, ETV6, ADD3 dels; ETV6-SRRM1 fusion |
IKZF1 del homo |
N |
na |
N |
N |
no |
| SJBALL074
|
D-G-R1 |
B |
5.1 |
na |
nd |
nd |
Minor |
CDKN2A/B del; KRAS sub x2, fall |
BRCA2, ZEB2 SNV |
NR3C2 CNA; KRAS, TBL1XR1 clonal SNVs |
N |
na |
N |
N |
no |
| SJBALL113
|
D-G-R1-R2 |
B |
4.3 |
1.3 |
B-other |
nd |
Polyclonal (D-R1), Polyclonal (R1-R2) |
FANCA SNV sub at D and R1, clonal R2 |
PAN3del, VPREB1del |
ATF7IP, TCF3 clonal R1 and R2; PTEN, RUNX1 SNV sub at R1 and fall. |
Y, R2=biphenotypic |
Clonally related major clone D->R1; Clonally related minor clone R1->R2
|
Y, Group 1 |
N |
no |
| SJBALL182
|
D-G-R1 |
B |
5.7 |
na |
B-other |
ZNF384 |
Minor |
NF1 del; NF1 and MLL2 SNVs sub and fall |
IKZF1, BTLA CNA, TAF15-ZNF384 fusion |
VPREB1 and CDKN2A/B del |
N |
na |
N |
N |
na |
| SJBALL192
|
D-G-R1-R2 |
B |
0.5 |
0.3 |
B-other |
nd |
Minor (D-R1), Minor (R1-R2) |
PTPN11 and XPO1 sub rise |
CDKN2A/B 2 copy del; PAX5 biallelic, IL7R |
NT5C2 (lost R2) |
N |
na |
N |
N |
na |
| SJBALL199
|
D-G-R1 |
B |
1.0 |
na |
DUX4 |
nd |
Major |
PAX5 SNV sub falls; IGH-DUX4 fusion |
ETV6 del; NR3C1 SNV |
VPREB1 del; FGFR1, BCL9, P2RY8 SNV sub |
N |
na |
N |
N |
R1 |
| SJERG003
|
D-G-R1 |
B |
5.3 |
na |
DUX4 |
nd |
Minor |
NRAS, NF1x2, KLF4 SNV sub fall; IGH-DUX4 fusion |
IKZF1 del; |
VPREB1, ERG, CDKN2A/B del; HNRNPA2B1, KIT SNV |
N |
na |
N |
N |
na |
| SJERG009
|
D-G-R1 |
B |
3.3 |
na |
DUX4 |
nd |
Minor |
NRAS SNV sub falls; NRAS SNV sub stays sub, RAD21 sub rises |
VPREB1, CDKN2A/B, ARID2 del, IGH-DUX4 fusion |
IKZF1, APC2 del; IKZF1, NR3C2 SNV sub |
N |
Clonally related major clone |
N |
N |
no |
| SJERG023
|
D-G-R1 |
B |
5.9 |
na |
DUX4 |
nd |
Major |
ERG, CDKN2A/B, ARID2 del; U2AF1, PIK3CA SNV fall |
None recurrent |
RB1, ERG, ARID2 del; FAM58A, FUS, MLL SNV clonal |
N |
Clonally related major clone |
N |
N |
na |
| SJERG025
|
D-G-R1 |
B |
9.9 |
na |
DUX4 |
nd |
Major |
MLL2 SNV falls |
IKZF1, ERG del |
MLL2 NCOR2 clonal |
N |
Clonally related minor clone |
N |
N |
no |
| SJETV010
|
D-G-R1-R2 |
B |
0.6 |
0.3 |
ETV6-RUNX1 |
nd |
Polyclonal (D-R1), Polyclonal (R1-R2) |
ARID2, CCND3 SNV sub fall; ETV6-RUNX1 fusion |
VPREB1, TBL1XR1, RAG1, FHIT, CDKN2A/B dels; KDM5C SNV, ETV6-RUNX1 fusion |
NR3C1x2, CTCF, PTEN, TP53 SNV clonal persist to R2; many SNV sub low MAF and
increase MAF but stay sub at R2 e.g. GATA3 |
N |
na |
Y, Group 1 |
N |
na |
| SJETV043
|
D-G-R1 |
B |
3.3 |
na |
ETV6-RUNX1 |
nd |
Minor |
None recurrent |
VPREB1, TBL1XR1, SLX4IP, NR3C1, FHIT, CDKN2A/B, BTLA, BTG1, ATF7IP del;
ETV6-RUNX1 fusion |
RAG1 del; PTPN11 and MLLT4 SNV clonal |
N |
na |
N |
Y |
no |
| SJETV047
|
D-G-R1-R2 |
B |
8.1 |
2.6 |
ETV6-RUNX1 |
nd |
Major (D-R1), Minor (R1-R2) |
Multiple SNV lost, ZNF697 sub rises |
ROR1 SNV, ETV6-RUNX1 fusion |
NR3C1 del; PER1 SNV |
N |
Clonally related minor clone D->R2; R1 sample failed |
N |
N |
no |
| SJETV048
|
D-G-R1 |
B |
4.2 |
na |
ETV6-RUNX1 |
nd |
Minor |
CDKN2A/B del; SETD2, NRAS sub fall |
VPREB1, PAX5, ATF7IP, ADD3 dels; ATF7IP SMV |
SLX4IP, CDKN2A/B, BTG1 del; ZNF384, CREBBBP, EP300, FAT3 SNV clonal; ETV6-RUNX1,
P2RY8-CRLF2, RUNX1-APOLD1, RUNX1-DDX47 fusions |
N |
na |
Y, Group 2 |
N |
na |
| SJETV138
|
D-G-R1 |
B |
4.2 |
na |
ETV6-RUNX1 |
Hyper |
Minor |
VPREB1 del; multiple non-recurrent fall and sub rise |
TBL1XR1, SLX4IP, NF1 del; GRIN2A SNV |
Multiple non-recurrent |
N |
na |
N |
N |
no |
| SJHYPER009
|
D-G-R1 |
B |
4.1 |
na |
Hyper |
nd |
Major |
None |
No R CNA data; NRAS |
None |
N |
na |
N |
N |
na |
| SJHYPER017
|
D-G-R1 |
B |
4.5 |
na |
Hyper |
nd |
Minor |
MLL2 SNV sub rises; ERBB4 SNV sub falls |
CDKN2A/B del; NRAS SNV |
TP63 |
N |
na |
N |
N |
no |
| SJHYPER021925
|
D-G-R1 |
B |
4.0 |
na |
Hyper |
nd |
Major |
GC, CXCR3 SNV sub fall |
PAX5, CDKN2A/B del; FLT3, CREBBP, PDGFRA SNV |
EVI5 SNV |
N |
na |
N |
N |
na |
| SJHYPER021999
|
D-G-R1 |
B |
4.0 |
na |
Hyper |
nd |
Minor |
CDKN2A/B del; NRAS and KRAS sub rise; NRAS sub falls |
CREBBP, ARID5B, HNRNPA2B1, CHD4 SNV |
CDKN2A/B del; TLX3 SNV. |
N |
na |
N |
N |
na |
| SJHYPER022
|
D-G-R1 |
B |
2.5 |
na |
Hyper |
nd |
Minor |
KRAS SNV sub rises at R, NRAS clonal falls |
CREBBP (LOH at R) |
MSH6 SNV sub |
N |
na |
Y, Group 1 |
N |
no |
| SJHYPER022423
|
D-G-R1 |
B |
8.8 |
na |
Hyper |
nd |
Major |
None recurrent |
MET, NRAS, APC2, PLAG1x2 SNVs; CREBBP SNV LOH at R |
CTCF, PIK3CA |
N |
na |
Y, Diagnosis |
N |
na |
| SJHYPER022424
|
D-G-R1 |
B |
7.0 |
na |
Hyper |
nd |
Major |
FLT3, ERG SNV sub fall |
None recurrent |
ETV6 SNV clonal; TCF7L2, NRAS sub |
N |
na |
N |
N |
na |
| SJHYPER027
|
D-G-R1-R2 |
B |
4.4 |
2.1 |
Hyper |
nd |
Major (D-R1), Major (R1-R2) |
None recurrent |
TRRAP SNV |
CDKN2A/B del |
N |
na |
Y, Preserved |
N |
na |
| SJHYPER098
|
D-G-R1 |
B |
1.3 |
na |
Hyper |
nd |
Minor |
IKZF1 del; NRASx2 1 clonal 1 sub fall |
CDKN2A/B del; SETD2 SNV |
IKZF1 del; BCL11A, NT5C2 SNV |
N |
na |
N |
N |
no |
| SJHYPER127
|
D-G-R1 |
B |
1.8 |
na |
Hyper |
nd |
Minor |
WHSC1 and BCL11A SNV sub rises, PMS1 SNV sub falls |
NR3C1, BTLA del |
Mant SNV absent at D: BCL11A, KLF6, EZH2, CDKN2A… |
N |
na |
Y, Group 3 |
N |
R1 |
| SJHYPO117
|
D-G-R1-R2 |
B |
1.2 |
0.5 |
Hypo |
iAMP21 |
Polyclonal (D-R1), Polyclonal (R1-R2) |
CREBBP sub falls |
PML, CREBBP |
None |
N |
na |
Y, Group 1 |
N |
R2 |
| SJHYPO126
|
D-G-R1 |
B |
0.4 |
na |
Hypo |
nd |
Polyclonal |
FANCA, BCL11A SNV low MAF, rise at R; ETV6-HBB fusion |
IKZF2 del |
TET1, MLLT1 SNV |
N |
na |
Y, Group 4 |
N |
no |
| SJHYPO146
|
D-G-R1-R2 |
B |
5.0 |
0.6 |
Hypo |
Ph-like |
Polyclonal (D-R1), Polyclonal (R1-R2) |
PAX5 sub falls |
PLAG1, CREBBP and NF1 rises |
None |
N |
na |
Y, Group 4 |
N |
R2 |
| SJINF001
|
D-G-R1 |
B |
2.6 |
na |
MLL |
INF |
Minor |
None recurrent |
KRAS SNV; KMT2A-AFF1 fusion |
IL21R, NR3C2 SNV UTR |
N |
na |
N |
N |
na |
| SJINF002
|
D-G-R1 |
B |
2.8 |
na |
MLL |
INF |
Minor |
None recurrent |
KMT2A-AFF1 fusion |
APC2 del; PAX5 SNV |
N |
na |
N |
N |
no |
| SJINF003
|
D-G-R1 |
B |
0.8 |
na |
MLL |
INF |
Minor |
KMT2A-AFF1 fusion |
None recurrent |
RPL22 SNV sub |
N |
Clonally related minor clone |
N |
N |
no |
| SJINF060
|
D-G-R1 |
B |
1.1 |
na |
MLL |
INF |
Major |
None recurrent |
KMT2A-MLLT1 fusion; ID2-IGK fusion |
PICALM del; WHSC1, CREBBPx2 SNV; SERINC3-ZCCHC7 fusion , CREBBP-DNAJA3 fusion
|
N |
na |
N |
N |
na |
| SJINF061
|
D-G-R1 |
T |
0.8 |
na |
TALL |
INF |
Minor |
KRAS SNV sub rises at R ; BICD2-JAK2 fusion |
PICALM CNA |
TBX3 SNV sub |
N |
na |
N |
N |
na |
| SJINF065
|
D-G-R1 |
B |
0.5 |
na |
MLL |
INF |
Minor |
TBA |
TBA |
KMT2A-AFF1, AFF1-BSX fusions |
N |
na |
N |
N |
no |
| SJINF068
|
D-G-R1 |
B |
0.3 |
na |
MLL |
INF |
Major |
TBA |
KMT2A-AFF1 fusion |
TBA |
N |
na |
N |
N |
no |
| SJINF073
|
D-G-R1 |
B |
0.3 |
na |
MLL |
INF |
Minor |
TBA |
KMT2A-MLLT3 fusion, JMJD1C-TSN fusion |
TBA |
N |
na |
N |
N |
no |
| SJMLL006
|
D-G-R1 |
B |
1.6 |
na |
MLL |
nd |
Major |
KRAS SNV clonal falls; KMT2A-AFF1 fusion |
CDKN2A/B del |
CDKN2A/B del; KDM6A SNV |
N |
na |
N |
N |
R1 |
| SJMLL022031
|
D-G-R1-R2 |
B |
1.2 |
0.7 |
MLL |
nd |
Major (D-R2) |
KMT2A-MLLT1 fusion |
IKZF1 del |
nd |
N |
na |
N |
N |
R2 |
| SJMLL026
|
D-G-R1 |
B |
0.5 |
na |
MLL |
nd |
Minor |
IKZF1 del; IL9R SNV sub falls |
ERG SNV, KMT2A-AFF1 fusion |
IKZF1, CDKN2A/B del; RUNX1 SNV sub; ZEB2-TXLNG fusion, NR3C1-TMEM241 fusion |
N |
na |
N |
N |
na |
| SJMLL039
|
D-G-R1 |
B |
1.2 |
na |
MLL |
nd |
Major |
HLF SNV sub falls |
KMT2A-AFF1 fusion |
TP53, RUNX1T1 SNV clonal |
N |
na |
N |
N |
na |
| SJPHALL002
|
D-G-R1 |
B |
2.5 |
na |
Ph |
nd |
Minor |
None recurrent (IGF2BP1 defines minor clone) |
PAX5, IKZF1, CDKN2A/B del; CCNE1 SNV sub |
MTOR SNV sub |
N |
na |
N |
N |
R1 |
| SJPHALL005
|
D-G-R1 |
B |
4.5 |
na |
Ph |
HYPER |
Precursor |
None |
BCR-ABL1 fusion? |
RUNX1, NCOR1 SNV clonal; BCORL1, RUNX1 SNV sub |
Y, R=biphenotypic |
Second Primary Tumor |
N |
N |
na |
| SJPHALL013
|
D-G-R1 |
B |
2.9 |
na |
Ph |
nd |
Minor |
None recurrent (CDH7 defines minor rising clone); BCR-ABL1 fusion |
VPREB1, SLX4IP, MEF2C, CDKN2A/B, BTLA, ABI1 CNA; SPOP SNV |
None recurrent |
N |
na |
N |
N |
na |
| SJPHALL018
|
D-G-R1 |
B |
1.2 |
na |
Ph |
nd |
Minor |
SLIT3 SNV sub rises |
VPREB1, IKZF1, CDKN2A/B del |
PRDM1 SNV sub |
N |
na |
N |
N |
na |
| SJPHALL020
|
D-G-R1 |
B |
0.7 |
na |
Ph |
nd |
Major |
BCR-ABL1 fusion |
TBA |
TBA |
N |
na |
N |
N |
na |
| SJPHALL022425
|
D-G-R1 |
B |
2.6 |
na |
Ph |
nd |
Precursor |
Multiple but none recurrent all fall |
IKZF1 different lesions; BCR-ABL1 fusion?, MAGIX SNV clonal |
Multiple non-recurrent |
N |
Second Primary Tumor |
N |
N |
no |
| SJPHALL029
|
D-G-R1-S |
B |
3.3 |
0.8 |
Ph |
nd |
Minor (D-R1) |
Multiple SNV sub fall none recurrent; BCR-ABL1 fusion |
IKZF1, CDKN2A/B del; multiple SNV none recurrent |
VPREB1 del; multiple SNV none recurrent |
N |
na |
N |
N |
S, not in study |
| SJTALL001
|
D-G-R1-R2 |
T |
1.1 |
1.0 |
ETP |
nd |
Minor (D-R1) |
ETV6 del; PTPN11, KRAS, ATF7IP SNV sub rise; FNBP1 + other SNV fall; MED14-HOXA9
fusion, ABCC9-ITPR2 fusion |
None recurrent |
CEBPA SNV clonal, NT5C2 subclonal (not at D) |
Y, R1=biphenotypic |
na |
N |
N |
R2 |
| SJTALL003
|
D-G-R1 |
T |
0.8 |
na |
ETP |
nd |
Minor |
IL7R, FBXW7x2, NOTCH1 SNV sub lost |
CDKN2A/B del; GATA3, PAX7, FBXW7x2, NOTCH1 |
RUNX1 SNV clonal |
N |
na |
N |
N |
na |
| SJTALL007
|
D-G-R1 |
T |
3.0 |
na |
ETP |
nd |
Minor |
JAK3, EP300, KDM6A, NOTCH1x2 SNV sub fall; IL7R, NOTCH1 SNV sub rise |
CDKN2A/B del; GATA3, ECT2L SNV |
KDM6A, NT5C2 SNV clonal; NT5C2 SNV sub |
N |
na |
Y, Preserved |
N |
na |
| SJTALL008
|
D-G-S |
T |
2.4 |
na |
ETP |
nd |
Polyclonal |
None recurrent |
SMARCA4, NRAS SNV clonal |
None recurrent |
Y, S=AML |
na |
N |
N |
S |
| SJTALL013
|
D-G-R1 |
T |
6.2 |
na |
ETP |
nd |
Minor |
DNM2, EZH2, NOTCH1x2, JAK1x2 SNV sub fall; NOTCH1 SNV sub low MAF rise |
PHF6, DNM2 SNV |
Many, none recurrent |
N |
na |
N |
N |
no |
| SJTALL023
|
D-G-R1-R2 |
T |
1.9 |
0.5 |
TALL |
nd |
Polyclonal (D-R1), Polyclonal (R1-R2) |
FOXP1 sub becomes clonal at R2 |
CDKN2A/B 2 copy del |
MSH2 2 copy del, many key genes that rise and fall |
N |
na |
Y, Group 3 |
Y |
R2 |
| SJTALL045
|
D-G-R1 |
T |
1.7 |
na |
TALL |
nd |
Major |
QKI SNV clonal persists, NOTCH1, BCL11B, MTOR, ERCC4 clonal and fall |
LEF1, CDKN2A/B del |
NRAS SNV clonal; NT5C2, NOTCH1x2, NR3C1, SMARCA4 SNV sub |
N |
na |
N |
N |
no |
| SJTALL049
|
D-G-R1-S |
T |
8.5 |
5.6 |
TALL |
TAL1 |
Precursor (D-R1), Second Primary Tumor (R1-S) |
CDKN2A 2 copy del, CDKN2Bdel; PTENx2, AUTS2, PAX5 SNV fall |
STIL del? |
LEF1del, CDKN2A/B 2 copy del, RB1 SNV sub |
Y, S=CML |
Second Primary Tumor 2x |
N |
N |
na |
| SJTALL050
|
D-G-R1-R2 |
T |
0.7 |
0.6 |
TALL |
TLX3 |
Minor (D-R1) |
NOTCH1 SNVx2 sub fall |
TLX3, CDKN2A/B CNA; WT1x2, DNM2 SNV clonal |
MYB gain |
N |
na |
N |
N |
R2 |
| SJTALL054
|
D-G-R1 |
T |
2.9 |
na |
TALL |
nd |
Minor |
BCL11B, WT1x2 SNV minor fall |
VRPEB1, CDKN2A/B del; WHSC1, PHF6, NOTCH1, AKT1, DNM2 SNV clonal |
MLL, ETV6 gain |
N |
na |
N |
N |
na |
| SJTALL055
|
D-G-R1 |
T |
1.2 |
na |
TALL |
nd |
Major |
TCF3 SNV sub fall |
None recurrent |
NOTCH1, PDGFB, CREBBP, TERT, HNF1A SNV clonal |
N |
Clonally related major clone |
N |
N |
na |
| SJTALL057
|
D-G-R1 |
T |
1.8 |
na |
TALL |
TAL1 |
Polyclonal |
PTEN SNVx2 clonal fall; several non-recurrent sub rise to be clonal |
STIL, CDKN2A/B del; MN1 |
Many SNV, biallelic MSH2 |
N |
na |
Y, Group 3 |
N |
na |
| SJTALL058
|
D-G-R1 |
T |
4.7 |
na |
TALL |
nd |
Minor |
IL7R clonal SNV fall |
CDKN2A/B |
IKZF1 del; FANCA, ITK SNV; WT1 homo, NRAS |
N |
na |
N |
N |
no |
| SJTALL091
|
D-G-R1 |
T |
1.9 |
na |
TALL |
nd |
Minor |
Multiple non-recurrent SNV fall |
NOTCH1, U2AF1, PTCH1, PTPN11, STAG2, KRAS, ETV6, RPL5, ARID1A (clonal) WT1 and
SRSF3 (sub) |
Highest MAF clone none recurrent; 2nd highest RARA, SH2B3, 3rd ROS1, 4th none
recurrent. |
N |
na |
Y, Group 2 |
N |
na |
| SJTALL092
|
D-G-R1 |
T |
1.6 |
na |
TALL |
nd |
Major |
MYCN, ATRX SNV clonal lost, NOTCH1, PLCG1 SNV sub lost |
CDKN2A/B del; ZFHX3 SNV clonal |
Many SNV none recurren |
N |
na |
N |
N |
na |
| SJTALL093
|
D-G-R1 |
T |
0.4 |
na |
TALL |
nd |
Polyclonal |
None recurrent |
CDKN2A/B del, NCOA4, IKZF1, STAT5B, LIFR SNV |
None recurrent |
N |
na |
N |
N |
na |
| SJTALL094
|
D-G-R1 |
T |
1.3 |
na |
TALL |
nd |
Major |
None recurrent |
CDKN2A/B del; ROS1, PAX3, BRD4 SNV |
None recurrent |
N |
na |
N |
N |
na |
| SJTALL098
|
D-G-R1 |
T |
1.0 |
na |
TALL |
nd |
Polyclonal |
FBXW7 SNV fall |
RUNX1 del; JAK3, TP53, LRPB1, LZTR1, NOTCH1 SNV |
None recurrent |
N |
na |
N |
N |
na |
| SJTALL124
|
D-G-S |
T |
1.2 |
na |
TALL |
nd |
Minor |
NOTCH1x2 SNV fall |
CDKN2A/B del, TP53, KIT, DDX3X, FUS SNV |
None recurrent |
Y, S=AML |
na |
N |
N |
na |
| SJTALL139
|
D-G-R1-R2 |
T |
2.7 |
1.0 |
TALL |
TAL1 |
Major (D-R1), Minor (R1-R2) |
CTCF, MYC, NOTCH1, FAT4 SNV sub fall |
STIL, CDKN2A/B del |
SF3B1, SMARCA4, LEF1 SNV, lost at R2 |
N |
na |
Y, Group 4 |
N |
R2 |
| SJTALL142
|
D-G-S |
T |
2.4 |
na |
TALL |
nd |
Second Primary Tumor |
CDKN2A/B del, MTOR, CCND3 SNV fall |
SIRT2 |
KRAS SNV sub |
Y, S=AML |
Second Primary Tumor |
N |
N |
no |
| SJTALL152
|
D-G-R1 |
T |
0.9 |
na |
TALL |
TAL1/TLX3 |
Polyclonal |
FAT4, FBXW7, NOTCH1x2, IL7R fall |
TLX3, STIL, CDKN2A/B del; FBXW7 SNV |
NT5C2 sub |
N |
na |
N |
N |
na |
| SJTALL161
|
D-G-R1 |
T |
1.9 |
na |
ETP |
nd |
Minor |
None |
NF1 del; ETV6, NRAS, NOTCH1, FAT4, CCND3, PHF6, XPO1 SNV |
BTG1 |
N |
na |
N |
N |
R1 |
| SJTALL164
|
D-G-S |
T |
1.5 |
na |
ETP |
nd |
Major |
None recurrent |
NF1, ATF7IP |
None recurrent |
Y, S=AML |
na |
N |
N |
no |